All experiments were conducted in negative ion mode. Analytes were detected as (M − H) ions.
Panels A1
and
A2. The extracted ion chromatogram and the mass spectrum of OAHFA with m/z 811.7549 (molecular formula C54H100O4). Note the presence of coeluting homologous ions 785.7396 and 837.7667.
Panels B1
and
B2. The extracted ion chromatogram and negative ion mode mass spectrum of OAHFA with m/z 783.7238 (molecular formula C52H96O4). Note the presence of coeluting homologous ions 757.7052 and 809.7388.
Panels C1
and
C2. The extracted ion chromatogram and negative ion mode mass spectrum of OAHFA with m/z 755.6944 (molecular formula C50H92O4). Note the presence of a coeluting homologous ion 781.7200.
Panel D. Profiles of OAHFA in female and male mouse tarsal plate samples (n=10, each group).
Panel E. The fragmentation pattern of the OAHFA C52H96O4. The major isoforms is shown.