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. Author manuscript; available in PMC: 2020 Sep 17.
Published in final edited form as: Circulation. 2019 Jul 18;140(12):1015–1030. doi: 10.1161/CIRCULATIONAHA.119.039710

Figure 8. Effect of the Cx43 hemichannel blocker TAT-Gap19 on intracellular calcium homeostasis in PKP2cKO mice.

Figure 8.

The left side (panels “a”) of panels A-D reproduce data presented in previous figures, for comparison. Transactivator of transcription (TAT)-Gap19 (panels “b”) normalized the increased Ca2+ transient magnitude (relative transient amplitude), sarcoplasmic reticulum (SR) load and elevated diastolic Ca2+ and reduced the spark frequency toward values similar to those measured in myocytes of plakophilin-2 conditional knockout (PKP2cKO)-left ventricle (LV) and in controls. Statistical analysis in right panels: Two-way repeated measures analysis of variance (ANOVA)-Bonferroni for Ca2+ transients, SR load and diastolic Ca2+. Hierarchical analysis for Ca2+ spark frequency. *p<0.05 vs. control. †p<0.05 vs. LV. 3 mice. Numbers in columns indicate number of cells tested.