Comparison 2.

Subgroups in univariable comparison of OS: PET+ve vs. PET‐ve

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 OS by radiotherapy	9	1802	Hazard Ratio (Random, 95% CI)	5.09 [2.64, 9.81]
1.1 Involved node and/or site	3	548	Hazard Ratio (Random, 95% CI)	3.45 [1.22, 9.72]
1.2 involved field	4	428	Hazard Ratio (Random, 95% CI)	12.75 [4.98, 32.68]
1.3 not specified	2	826	Hazard Ratio (Random, 95% CI)	2.80 [1.17, 6.67]
2 OS by study design	8	1717	Hazard Ratio (Random, 95% CI)	4.63 [2.43, 8.80]
2.1 Prospective	3	406	Hazard Ratio (Random, 95% CI)	5.35 [1.07, 26.68]
2.2 Retrospective	4	589	Hazard Ratio (Random, 95% CI)	7.12 [3.14, 16.14]
2.3 RCT	1	722	Hazard Ratio (Random, 95% CI)	2.60 [1.03, 6.56]
3 OS by chemotherapy	9	1802	Hazard Ratio (Random, 95% CI)	5.09 [2.64, 9.81]
3.1 ABVD	5	801	Hazard Ratio (Random, 95% CI)	5.19 [2.11, 12.72]
3.2 ABVD and/or other	3	279	Hazard Ratio (Random, 95% CI)	10.30 [1.71, 62.13]
3.3 BEACOPP	1	722	Hazard Ratio (Random, 95% CI)	2.60 [1.03, 6.56]
4 OS for PET/CT vs PET	8	1706	Hazard Ratio (Random, 95% CI)	5.01 [2.50, 10.02]
4.1 PET/CT	5	595	Hazard Ratio (Random, 95% CI)	4.70 [1.86, 11.86]
4.2 PET only	3	1111	Hazard Ratio (Random, 95% CI)	6.99 [1.58, 30.90]
5 OS by disease stage	9	1802	Odds Ratio (Random, 95% CI)	5.09 [2.64, 9.81]
5.1 Stages I and II with A and B symptoms	1	96	Odds Ratio (Random, 95% CI)	9.21 [0.71, 120.03]
5.2 All stages	7	984	Odds Ratio (Random, 95% CI)	6.28 [2.62, 15.05]
5.3 Advanced	1	722	Odds Ratio (Random, 95% CI)	2.60 [1.03, 6.56]
6 Timing of interim PET	9	1802	Hazard Ratio (Random, 95% CI)	5.09 [2.64, 9.81]
6.1 PET2	6	1495	Hazard Ratio (Random, 95% CI)	3.53 [1.97, 6.32]
6.2 Other (including mixed)	3	307	Hazard Ratio (Random, 95% CI)	20.13 [5.04, 80.38]
7 OS by HR type of estimation	9	1802	Hazard Ratio (Random, 95% CI)	5.09 [2.64, 9.81]
7.1 precise	7	1638	Hazard Ratio (Random, 95% CI)	5.70 [2.60, 12.48]
7.2 Imprecise	2	164	Hazard Ratio (Random, 95% CI)	3.60 [0.89, 14.64]