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. 2019 Sep 16;9:13333. doi: 10.1038/s41598-019-50046-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Autoregulation curve Combined changes in LDF (blue) and RBC flux (red) for 10 hypotensive and 10 hypertensive experiments plotted against CPP. Grey shading represents the standard error (for the LDF data curve there was no visible standard error). Dotted lines show the mean lower and upper limits of autoregulation determined by segmented regression analysis of individual experiments as described in Table 2. Differences between breakpoints were not statistically significant for the lower (hypotensive experiments, p = 0.25) and upper (hypertensive experiments, p = 0.72) limits of autoregulation.