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. 2019 Sep 16;9:13356. doi: 10.1038/s41598-019-49817-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Differentially expressed proteins across preimplantation development and their functional enrichment. (A) Number of differentially expressed proteins between pairs of consecutive developmental stages (fold-change ≥2 or ≤0.5 between any two developmental stages, P-value ≤ 0.05 from ANOVA). (B) Expression profile of protein clusters. The heatmaps show fold-changes relative to the oocyte scaled using the z-score transformation. The height of the heatmaps is proportional to the number of proteins in each cluster, which is also indicated. The median fold-change across all cluster members for each developmental stage is represented below the heatmaps. (C) Annotation of protein clusters. Gene Ontology (GO) terms associated (FDR ≤ 0.05) with each cluster were summarized with REVIGO⁸⁹. REVIGO “representatives” for the individual GO terms are listed on the right of the heatmap. Statistical significance (sum of the -log₁₀ FDR of the individual GO terms) for the annotation of each of the clusters is represented using a color gradient. Non-significant associations are represented in gray. Details are presented in Supplemental Table S2.