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. 2019 Sep 16;9:13393. doi: 10.1038/s41598-019-49706-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The HCV-antigen responsible for suppressing the expression of hsa-miR146b-5p in monocytes and T cells. The relative expression of miR146b-5p in THP-1 (A) and Jurkat (D) cells is shown after the transfection of various kinds of HCV antigen expressing plasmids (HCV-core, E1, E2, NS3, NS4B, NS5A and NS5B) with or without JFH-1 full length strain. The relative expressions of miR146b-5p in THP-1 (B) and Jurkat (E) cells are shown after adding the extra-cellular HCV-core protein. The relative expressions of hsa-miR146b-5p in CD14⁺ monocytes (C) and CD3⁺ T cells (F) from IL28B T/T subjects and IL28B T/G subjects were analyzed after adding the extra-cellular HCV-core protein. Error-bars indicate standard deviation.