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. 2019 Sep 16;9:13316. doi: 10.1038/s41598-019-49649-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Adipocytes enhance ovarian cancer cell chemoresistance. (A) Human OvCa cells OVCAR5, CAOV3 and SKOV3 were incubated with adipocyte CM and different concentrations of cisplatin. Cell viability was analyzed 72 hours later. (B) Ovarian cancer cells were incubated with adipocyte CM together with different concentrations of paclitaxel or doxorubicin. (C) OVCAR5 cells were incubated with CM from visceral adipocytes (visAdi_CM), together with cisplatin. (D) Apoptosis marker cleaved PARP was analyzed in lysates from OVCAR5 cells treated with cisplatin and subcutaneous (subAdi_CM) or visceral adipocyte CM (visAdi_CM). *p < 0.05, **p < 0.01 and ***p < 0.001.