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. 2019 Sep 16;9:13316. doi: 10.1038/s41598-019-49649-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Adipocyte CM and arachidonic acid increase chemoresistance in both chemo-sensitive and -resistant ovarian cancer cells. Chemosensitve PEO1 cells (A) and chemoresistant PEO4 cells (B) were incubated with adipocyte CM and different concentrations of cisplatin. PEO1 cells (C) and PEO4 cells (D) were also treated with 5 μM or 20 μM cisplatin, respectively, and different concentrations of arachidonic acid (AA). Cell viability was analyzed 72 hours later. *p < 0.05, **p < 0.01 and ***p < 0.001.