Table 3.
Association of lipid genetic scores with CRC.
| Risk alleles in controls | Risk alleles in cases | ORa per 10 risk alleles | 95% CI | P-value | |
|---|---|---|---|---|---|
| Mean ± sd | Mean ± sd | ||||
| TG | 23.44 ± 2.91 | 23.34 ± 2.82 | 0.91 | 0.72–1.16 | 0.44 |
| HDL | 38.05 ± 3.75 | 38.13 ± 3.75 | 1.14 | 0.95–1.37 | 0.16 |
| LDL | 40.71 ± 3.80 | 40.69 ± 3.80 | 0.97 | 0.81–1.16 | 0.73 |
| TC | 49.06 ± 4.11 | 49.00 ± 4.07 | 0.99 | 0.84–1.17 | 0.89 |
| Statins non-users | |||||
| TG | 23.40 ± 2.90 | 23.28 ± 2.83 | 0.90 | 0.69–1.18 | 0.46 |
| HDL | 38.04 ± 3.81 | 38.17 ± 3.72 | 1.20 | 0.98–1.47 | 0.076 |
| LDL | 40.50 ± 3.79 | 40.58 ± 3.75 | 1.06 | 0.87–1.30 | 0.56 |
| TC | 48.91 ± 4.08 | 48.86 ± 4.03 | 1.03 | 0.85–1.25 | 0.76 |
| Statins users | |||||
| TG | 23.62 ± 2.93 | 23.56 ± 2.74 | 0.99 | 0.58–1.71 | 0.98 |
| HDL | 38.13 ± 3.50 | 37.95 ± 3.92 | 0.91 | 0.59–1.39 | 0.64 |
| LDL | 41.57 ± 3.74 | 41.19 ± 3.97 | 0.74 | 0.49–1.12 | 0.15 |
| TC | 49.72 ± 4.17 | 49.59 ± 4.17 | 0.91 | 0.63–1.32 | 0.63 |
TG: triglycerides; HDL: high density lipoprotein cholesterol; LDL: low density lipoprotein cholesterol; TC: total cholesterol. All genetic scores are coded as increasing lipid levels.
aORs and 95% CI derived from logistic regression models adjusted for the study design factors (age, sex, center and education). The quantitative genetic score calculated as the sum of risk alleles was divided by 10.