Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Sep 16;6:173. doi: 10.1038/s41597-019-0179-2

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

The Creative Commons Public Domain Dedication waiver http://creativecommons.org/publicdomain/zero/1.0/ applies to the metadata files associated with this article.

PMC Copyright notice

Fig. 2 — Analysis of ERα interactome changes upon RNase treatment. (a) Venn diagram showing the overlap between ERα molecular partners identified by Tandem affinity purification (TAP) before and after RNase treatment and Volcano plot summarizing quantitative changes of ERα-associated overlapping proteins upon treatment with RNase. Dotted line (threshold) represents the cut-off (q-value ≤ 0.05). (b) Classification of ERα molecular partners; asterisks indicate statistically significant molecule types (p < 0.01 hypergeometric test). (c) Functional enrichment analysis by IPA of ERα-associated proteins (B-H: Benjamini-Hochberg corrected p-value). (d) Network representation of the ESR1-TRAP/Mediator coactivator-complex; thickness of links (lines) among nodes (proteins) is proportional to the strength of the physical interaction. Information about co-expression, physical interactions and strength derive from GeneMANIA.