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. 2019 Sep 10;10:2143. doi: 10.3389/fimmu.2019.02143

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Copyright © 2019 Pellefigues, Mehta, Prout, Naidoo, Yumnam, Chandler, Chappell, Filbey, Camberis and Le Gros.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Analysis of the specificity of DTR expression in B8xiDTR mice. (A) Expression of HBEGF was analyzed by RTqPCR on FACS sorted eYFP⁺ Basophils, CD11b⁺ SiglecF⁺ SSC^hi Eosinophils, CD11b⁺ Ly6G⁺ Neutrophils from the spleens and CD11b⁺ CD64⁺ Macrophages, CD19⁺ B cells or CD11b⁻ CD64⁻ CD200R3⁺ cKit⁺ Mast cells from the peritoneal lavages of B8xiDTR or B8xC57 mice infected for 15 days with Hp (for the spleens) or not (peritoneum), and normalized to their expression of GAPDH (n = 5). (B) Illustration of the expression of HBEGF by B8xiDTR immune cells from (A) as a % of the mean expression by B8xiDTR basophils. Data are representative of at least two independent experiments giving similar results. Statistical analyses are a two-way ANOVA with a Sidak post-test comparing the different genotypes for each immune cell population. Ns, Non significant; ^****p < 0.0001.