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. 2019 Sep 10;10:2133. doi: 10.3389/fimmu.2019.02133

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Copyright © 2019 Pasquin, Tormo, Moreau, Laplante, Sharma, Gauchat and Rafei.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CLCF1 administration to healthy mice up-regulate LSK and myeloid cell levels in the BM. (A,B) Frequency and count assessment of LSKs at day 8 post-CLCF1 administration. (C) Absolute counts of BM LSKsCD150⁺CD48⁻ (LT-HSCs), LSKsCD150⁻CD48⁻ (ST-HSCs), LSKsCD150⁺CD48⁺ (MPP2), and LSKsCD150⁻CD48⁺ (MPPs). (D) Absolute counts of BM-, blood- and spleen-resident CD11b⁺ cells, CD19⁺ cells and CD3⁺ cells at day 8. Graphs represent absolute count in mean ± S.D (n = 5 per group). ^*P < 0.05, ^**P <0.01, ^***P < 0.001.