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. 2019 Sep 10;13:409. doi: 10.3389/fncel.2019.00409

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Copyright © 2019 Higham, Hidalgo, Buhl and Hodge.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Tau expression increased Ca²⁺ channelα1D mRNA levels. Pan-neuronal Tau expression led to a 68% increase in Ca-α1D mRNA levels compared to controls, while expressing a RNAi against Ca-α1D reduced its expression by 58%. Co-expression of the RNAi in tau expressing flies partially restored levels of Ca-α1D compared to controls. n = 6 biological replicates of 23 or more heads each for all groups. Data analyzed with one-way ANOVA with Holm-Sidak’s post hoc tests. ^∗p < 0.05.