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. 2019 Sep 10;13:411. doi: 10.3389/fncel.2019.00411

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Copyright © 2019 Bradford, Wijaya and Mabbott.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CD44v6 expression and PrP^d colocalize with GFAP + astrocytes in the brains during prion disease. (A) Immunohistochemical demonstration of astrocytic PrP^d immunostaining patterns in brains of mice infected with certain prion agent strains. (B,C) Immunohistochemical analysis shows pan-CD44 expression surrounds but does not co-localize with GFAP in astrocytes. (D) Immunostaining for CD44v6 shows astrocytic staining pattern suggesting that astrocytes are the predominant cellular source of CD44 upregulation during prion disease. A–C scale bars = 100 μm. (E) Immunofluorescent analysis of CD44, GFAP and PrP^d in the brains of mice with prion disease shows that CD44+ /GFAP+ astrocytes accumulate PrP^d. Scale bars = 20 μm.