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. 2019 Sep 10;13:411. doi: 10.3389/fncel.2019.00411

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Copyright © 2019 Bradford, Wijaya and Mabbott.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Histopathological detection of amyloid and activated glial cells in the brain following prion infection. (A) Thioflavin-S staining of normal brain C57Bl/Dk, 87V-VM/Dk, 409V-C57Bl/Dk and 409V-VM/Dk prion agent strain and host combinations revealed characteristic amyloid deposits in the brains of mice with amyloidal PrP accumulations. Images are representative of N = 4 mice/group. Scale bars = 100 μm. (B) Immunohistochemical detection of microglia (AIF1+ cells, upper row) and astrocytes (GFAP+ cells, lower row). This analysis showed minimal AIF1+ and GFAP+ immunostaining in the brains of uninfected control mice, whereas expression of these markers was strongly upregulated in brains of mice with terminal prion disease. Representative images N = 6 mice/group are shown. Scale bars = 500 μm.