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. 2019 Sep 10;9:874. doi: 10.3389/fonc.2019.00874

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Copyright © 2019 Amantini, Morelli, Nabissi, Piva, Marinelli, Maggi, Bianchi, Bittoni, Berardi, Giampieri and Santoni.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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OS, OS1, and PFS according to CTC or CTC cluster number. (A–C) OS, OS1, and PFS were evaluated stratifying patients according to H (High, more than 10 CTCs/ml) or L (Low, <10 CTCs/ml) CTCs amount. (D–F) OS, OS1, and PFS, were evaluated stratifying patients according to presence (Yes) or not (No) of CTC clusters. p < 0.05 was considered as statistically significant.