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. 2019 Sep 16;9:13416. doi: 10.1038/s41598-019-49933-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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H&E histological assessment of transplanted islets: (a) Representative H&E histological staining of islets that were transplanted under the kidney capsule. Black arrows = islets; Green arrows = blood vessels; (b) Quantification of microvessel density within islets. In this figure, control samples (transplanted islets with no treatment) are compared to transplanted islets treated with pFUS. Significant differences: *P < 0.05 for transplanted islets only vs. islets treated with pFUS (Student’s unpaired t-test).