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. 2019 Sep 10;10:2102. doi: 10.3389/fmicb.2019.02102

FIGURE 3.

FIGURE 3

IFN-γ is required for optimal control of M. africanum, but its absence does not lead to overt disease. C57BL/6 WT (black circles or bars) and IFN-γ–/– (white circles or bars) mice were infected by aerosol with a low dose (<200 CFU) of M. africanum. (A) The weight of the animals was monitored weekly up to day 90. On day 90 post-infection, (B) lungs, spleens, and livers of infected mice were collected and the bacteria burden determined by CFU enumeration and (C) lungs were harvested and pathology determined by H&E staining. Data are shown as mean ± SEM from five animals per group. The images in (C) are of one animal representative of the experimental group. Scale bar on the left and right images correspond to 1 mm and 100 μm, respectively. Unpaired t-test was used to perform the statistical analysis. ∗∗∗p < 0.001; ****p < 0.0001.