FIGURE 3.

Mesenteric single-unit afferent sensory signaling is decreased in aged mice. (A) Multi-unit mesenteric afferent firing from the mesenteric nerve in old mice compared to young mice (N = 10 mice). (B) Single-unit mesenteric afferent firing from the mesenteric nerve had longer interspike intervals, indicating decreased afferent firing in old mice (N = 121 and 149 fibers). (C) Representative traces of mesenteric afferent firing for young mice, and (D) mesenteric afferent firing for old mice. Data represented as mean with SEM, t-test unpaired, two-tailed, with Welch’s correction.