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. 2019 Sep 10;9:322. doi: 10.3389/fcimb.2019.00322

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Copyright © 2019 Huang, Huang, Chen, Liu, Wu, Wang, Li, Li, Gao, Cen, Lin, Liu and Jin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The number of MCs and percentage of MCs degranulation in CLN or skin from PbANKA-infected mice with C48/80 or DSCG treatment. (A,B) MCs were evaluated by toluidine blue staining in CLN (magnification, x400) or skin (magnification, x400) from the uninfected mice treated with saline (a), C48/80 (d), or DSCG (g), and the infected mice treated with saline (b), C48/80 (e), or DSCG (h) at 4 days p.i, respectively; infected mice treated with saline (c), C48/80 (f), or DSCG (i) at 9 days p.i., respectively; Intact MCs (arrowheads); Degranulated MCs (arrows). (C) The density of MCs in CLN or skin tissue were analyzed from different groups by using Student's t-test. *P < 0.05 and **P < 0.01 vs. the Naive mice, ^#P < 0.05 and ^##P < 0.01 vs. the infected controls at 4 days p.i., ^&P < 0.05 and ^&&P < 0.01 vs. the infected controls at 9 days p.i.; (D) the level of degranulated MCs in CLN or skin tissue were analyzed from different groups by using Student's t-test. ^§P < 0.05 and ^§§P < 0.01 vs. the Naive mice, ^$P < 0.05 and ^$$P < 0.01 vs. the C48/80 group, P < 0.05 and P < 0.01 vs. the DSCG group. There were four to six mice per group, and the data were representative of three experiments.

Inline graphic — The number of MCs and percentage of MCs degranulation in CLN or skin from PbANKA-infected mice with C48/80 or DSCG treatment. (A,B) MCs were evaluated by toluidine blue staining in CLN (magnification, x400) or skin (magnification, x400) from the uninfected mice treated with saline (a), C48/80 (d), or DSCG (g), and the infected mice treated with saline (b), C48/80 (e), or DSCG (h) at 4 days p.i, respectively; infected mice treated with saline (c), C48/80 (f), or DSCG (i) at 9 days p.i., respectively; Intact MCs (arrowheads); Degranulated MCs (arrows). (C) The density of MCs in CLN or skin tissue were analyzed from different groups by using Student's t-test. *P < 0.05 and **P < 0.01 vs. the Naive mice, ^#P < 0.05 and ^##P < 0.01 vs. the infected controls at 4 days p.i., ^&P < 0.05 and ^&&P < 0.01 vs. the infected controls at 9 days p.i.; (D) the level of degranulated MCs in CLN or skin tissue were analyzed from different groups by using Student's t-test. ^§P < 0.05 and ^§§P < 0.01 vs. the Naive mice, ^$P < 0.05 and ^$$P < 0.01 vs. the C48/80 group, P < 0.05 and P < 0.01 vs. the DSCG group. There were four to six mice per group, and the data were representative of three experiments.