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Clinical trials of therapeutics targeting ERS and UPR.
| Compound | Disease | Targeted mechanisms | Clinical trial phase | Reference |
|---|---|---|---|---|
| Tauroursodeoxycholic acid (TUDCA) | Insulin resistance | ERS | N/A | NCT00771901 |
| Sodium phenylbutyrate (PBA) | Insulin resistance | ERS | N/A | NCT00771901 |
| Liraglutide | Type 2 diabetes | ERS | Phase 4 | NCT02344186 |
| Buphenyl | Diabetes Insulin resistance |
ERS | Phase 4 | NCT00533559 |
| Alpha-lipoic acid (ALA) | Type 2 diabetes Prediabetes |
ERS | Phase-4 | NCT01056497 |
