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FOXG1 interacts with members of different signaling pathways—including the Shh, WNT, IGF, Hippo, SMAD, TGF, Notch, and EGF signaling pathways—that are important in neurodevelopment, and promotes proliferation, survival, and differentiation of neurons or other cell types. It exerts critical impacts on neurogenesis and patterning of the telencephalon, and may also be associated with tumorigenesis.
