Table 5.
Integrin subunit pairing and binding ligands [76,77,82,83,84]. VCAM: vascular cell adhesion molecule, ICAM: intercellular adhesion molecule, LAP: latency-associated peptide, TGF-β: transforming growth factor beta, vWF: von Willebrand factor.
| Integrin Subunit | Ligand | |
|---|---|---|
| β | α | |
| β1 | α1 | Collagen, Laminin |
| α2 | Collagen, Laminin, Thrombospondin, E-cadherin, Tenascin C | |
| α10 | Collagen, Laminin | |
| α11 | Collagen | |
| α3 | Laminin, Thrombospondin | |
| α6 | Laminin | |
| α7 | Laminin, Tenascin C | |
| β4 | α6 | Laminin, Thrombospondin |
| β1 | α4 | Fibronectin, Thrombospondin, Osteopontin, VCAM-1, ICAM-4 |
| α5 | Fibronectin, Osteopontin | |
| α8 | Fibronectin, Vitronectin, Osteopontin, Tenascin C | |
| α9 | Osteopontin, Tenascin C, VCAM-1 | |
| αV | Fibronectin, Osteopontin, LAP TGF-β | |
| β5 | αV | Vitronectin, Osteopontin, LAP TGF-β |
| β6 | Fibronectin, Osteopontin, Tenascin C, LAP TGF-β | |
| β8 | LAP TGF-β | |
| β3 | Fibrinogen, Fibronectin, vWF, Vitronectin, Thrombospondin, Osteopontin, ICAM-4, Tenascin C | |
| β3 | αIIb | Fibrinogen, Fibronectin, vWF, Vitronectin, Thrombospondin, ICAM-4 |
| β7 | α4 | Fibronectin, Osteopontin, VCAM-1, |
| Leukocyte-Specific | ||
| β7 | αE | E-cadherin |
| β2 | αL | ICAM-4 |
| αM | Fibrinogen, ICAM-4 | |
| αX | Fibrinogen, ICAM-4, Collagen | |
| αD | Fibronectin, Vitronectin, Fibrinogen, VCAM-1, ICAM-3 | |