Table 8.

Sensing information transfer between the cell surface and nucleus.

Main Findings	Ref.
LINC complexes act as bridges across the perinuclear space by coupling KASH family members and SUN family members.	[101,115,116]
The cytoplasmic domains of the KASH proteins interact with cytoskeletal elements and the exposed residues of the KASH proteins bind to the C-termini of SUN proteins.	[116]
N-termini of SUN proteins bind to the nuclear lamins.	[116]
YAP/TAZ complex provides bidirectional biochemical connections.	[113,114,115]
YAP/TAZ-mediated regulation requires Rho GTPase activity and tension of the actin cytoskeleton.	[113]
LINC complex-mediated nuclear mechanotransduction can be induced when the signal molecules phosphorylate several structural proteins.	[115]