Figure 7.

Schematic representation of the proposed orientations of tachyplesin peptides and cyclic analogues, when inserted into negatively-charged membranes based on the tryptophan fluorescence quenching, results with 5- and 16DS. The phospholipids in grey represent PC headgroups and the phospholipids in red represent PS headgroups. The peptides have a backbone length of approximately 25 Å (measured in PyMol) and are able to span across a lipid monolayer. Other orientations are possible. The distribution of the 5DS and 16DS quencher within a phospholipid bilayer was illustrated based on previous publications [60,63].