Table 4.
Activity of tachyplesin I–III (TI–TIII) and cyclic analogues (cTI–cTIII) against S. aureus ATCC 6538 in the biofilm growth form.
| Peptide | CC50 (µM) 1 | Metabolically Active Cells (%) 2 |
|---|---|---|
| TI | 21.5 ± 2.2 | 37.7 ± 4.3 |
| TII | 23.1 ± 2.9 | 39.9 ± 2.9 |
| TIII | 24.2 ± 4.1 | 43.3 ± 4.1 |
| cTI | 17.8 ± 3.6 | 31.9 ± 6.0 |
| cTII | 19.4 ± 1.5 | 34.6 ± 7.1 |
| cTIII | 18.0 ± 1.4 | 37.5 ± 7.2 |
1 Peptide concentration required to induce the reduction of 50% of the metabolically active cell population (CC50) determined using one-site specific binding with the Hill slope. 2 Percentage of cells remaining metabolically active at 32 µM, the highest peptide concentration tested.