Table 6.

Main topological parameters assessed. The twelve main topological parameters that have been examined are defined.

Parameter	Definition
Connected Components	Number of networks in which any two vertices are connected to each other by links, and which is connected to no additional vertices in the network.
Number of nodes	Total number of molecules involved.
Number of edges	Total number of interactions found.
Clustering coefficient	Calculated as CI = 2nI/kI(kI–1), where nI is the number of links connecting the kI neighbors of node I to each other. It is a measure of how the nodes tend to form clusters.
Network diameter	The longest of all the calculated shortest paths in a network.
Shortest paths	The length of the shortest path between two nodes n and m is L (n, m). The shortest path length distribution gives the number of node pairs (n, m) with L(n,m) = k for k = 1,2,…
Characteristic path length	Expected distance between two connected nodes.
Averaged number of neighbors	Mean number of connections of each node.
Node degree	It is the number of interaction of each node.
Node degree distribution	It represents the probability that a selected node has k links.
γ	Exponent of node degree equation.
R2	Coefficient of determination of node degree vs. number of nodes, on logarithmized data.