Table 1.
Characteristics of Heat Shock Proteins usually investigated in sepsis.
| Family | Heat Shock Protein (Molecular Weight) | Localization | Function |
|---|---|---|---|
| Small HSPs [79,80] | HSP 25 * (22 kDa) | Cytosol-nucleus [80] | Chaperone [79] Immune cell activation [15] |
| HSP 27 (22 kDa) | Cytosol-nucleus [79,81] | ||
| HSP 40 (38 kDa) | Cytosol [79,81] nucleus [81] | ||
| HSP 60 [79] | HSP 60 (61 kDa) | Cytosol-mitochondria [79,81] | Chaperone [79] Immune cell activation [15,16] |
| HSP 70 [79] | HSP 70 (70 kDa) | Cytoplasm [79,81]-nucleus [81] | Chaperone [79] Immune cell activation [15,16] |
| HSP 72 (71 kDa) | Cytosol-Nucleus [81] | ||
| HSP 73 / HSC 70 (71 kDa) | Cytosol [79,81] Nucleus [81] | ||
| HSP 90 [79] | HSP 90A (86 kDa) | Cytosol [79,81] Nucleus [81] | Chaperone [79] Immune cell activation [15,16] |
| HSP 90B (84 kDa) | Cytosol [79,81] Nucleus [81] | ||
| GRP94 (92 kDa) | ER [79,81] Cytosol [79] | ||
| Large HSPs [79] | HSP 110 (96 kDa) | Nucleus [81] Cytosol [79] | Chaperone [79] |
* HSP25 in animals is called HSP27 in human cells.