Table 2.
Anticarcinogenic effect of B. longum microencapsulates on the macroscopic quantitative classification of colonic lesions induced with AOM and DSS in male CD-1 mice.
| Group | n | Incidence of Early Lesions a (%) | Mean Number b | Colon Distribution of Early Lesions a | Incidence of Tumors c (%) | Mean Number b | Colon Distribution of Tumors c | ||
|---|---|---|---|---|---|---|---|---|---|
| Proximal | Distal | Proximal | Distal | ||||||
| Normal | 10 | 10% * | 0.1 ± 0.1 b | 1 (100%) | 0 (0%) | 0% * | 0.0 ± 0.0 b | 0 (0%) | 0 (0%) |
| AOM + DSS control | 10 | 60% | 1.2 ± 0.4 ab | 2 (17%) | 10 (83%) | 80% | 4.2 ± 1.0 a | 0 (0%) | 42 (100%) |
| BF + AOM + DSS | 7 | 86% | 2.4 ± 0.7 ab | 1 (6%) | 16 (94%) | 14% * | 0.1 ± 0.1 b | 0 (0%) | 1 (100%) |
| BF + LYC 20 AOM + DSS | 8 | 88% | 3.0 ± 0.6 a | 4 (17%) | 20 (83%) | 13% * | 0.1 ± 0.1 b | 0 (0%) | 1 (100%) |
| BF + LYC 50 AOM + DSS | 8 | 75% | 2.3 ± 0.7 ab | 4 (25) | 12 (75%) | 38% * | 0.4 ± 0.2 b | 1 (33%) | 2 (67%) |
| LYC 20 + AOM + DSS | 7 | 71% | 1.1 ± 0.5 ab | 0 (0%) | 8 (100%) | 43% | 1.7 ± 1.0 ab | 0 (0%) | 12 (100%) |
| LYC 50 + AOM + DSS | 7 | 71% | 1.3 ± 0.4 ab | 3 (33%) | 6 (67%) | 71% | 1.6 ± 0.6 ab | 1 (9%) | 10 (91%) |
| Metformin + AOM +DSS | 6 | 83% | 2.2 ± 0.9 ab | 11 (85%) | 2 (15%) | 50% | 0.5 ± 0.2 b | 2 (67%) | 1 (33%) |
a Macroscopic quantitative evaluation of flat-type lesions. b Lesion burden/number of mice per group. c Macroscopic quantitative evaluation of protuberant (pedunculate, sessile, exophytic and endophytic) lesions. Values are mean ± SEM. Values with different letter(s) within a column are significantly different by Tukey test (p < 0.05). * Incidence is statistically significant by Chi-square test (p < 0.05).