Table 1.

Host factors that promote or repress HBV cccDNA activity.

Name	Function	Effect on cccDNA	References
HNF1	Transcription factor	Activation	[66,67,68]
HNF3/FoxA	Transcription factor	Activation	[69,70,71,72,73]
HNF4	Nuclear receptor	Activation	[68,74]
C/EBP	Transcription factor	Activation	[75,76]
RXRα/PPARα	Nuclear receptor	Activation	[77,78]
FXR	Nuclear receptor	Activation	[79]
NF1	Transcription factor	Activation	[80,81]
SP1	Transcription factor	Activation	[82,83,84]
AP-1	Transcription factor	Activation	[85,86]
TBP	Transcription factor	Activation	[87,88]
CREB	Transcription factor	Activation	[89,90]
Oct1	Transcription factor	Activation	[67]
NRF1	Transcription factor	Activation	[91]
CRTC1	Transcriptional coactivator	Activation	[65]
CBP	HAT	Activation	[92]
p300	HAT	Activation	[92]
PCAF/GCN5	HAT	Activation	[92]
LSD1	Histone demethylase	Activation	[93]
Set1A	KMT	Activation	[93]
NF-κB	Transcription factor	Inhibition	[94]
PROX1	Transcription factor	Inhibition	[95]
STAT1/2	Transcription factor	Inhibition	[96,97]
EZH2	KMT	Inhibition	[97]
YY1	Transcription factor	Inhibition	[97,98]
SIRT1	Class III HDAC	Inhibition	[85,97]
SIRT3	Class III HDAC	Inhibition	[99]
PRMT1	PRMT	Inhibition	[100]
PRMT5	PRMT	Inhibition	[101]
HDAC1	Class I HDAC	Inhibition	[97]
SETDB1	KMT	Inhibition	[102]
Smc5/6	Structural maintenance of chromosomes	Inhibition	[103]
ZHX2	Transcription factor	Inhibition	[104]
DDX3	DEAD-box RNA helicase	Inhibition	[105]
APOBEC3A	Cytidine deaminase	Inhibition	[58]
APOBEC3B	Cytidine deaminase	Inhibition	[58,106]