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. 2019 Aug 26;16(17):3101. doi: 10.3390/ijerph16173101

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Possible effects of intermittent hypoxia (IH) on glucose-induced insulin secretion and β cell proliferation. IH causes the downregulation of CD38 to decrease glucose-induced insulin secretion, as well as the upregulation of IL-6. IL-6 increases the expression of Reg family genes and HGF gene Reg family members function as growth factors for pancreatic β cells and HGF works as an antiapoptotic factor. As a result, pancreatic β cells with decreased glucose-induced insulin secretion are increased.