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The effects of chronic application of IMD (50 pM, 0.11 µL/hr) in the PVN for 28 days on the plasma NE level (A), systolic blood pressure (B), PVN NADPH oxidase activity and ROS content in control and OH rats (C,D); and RSNA and MAP responses to Ang II (0.3 nM) in the PVN of OH rats (E,F). Values are mean ± SEM. * p < 0.05 versus control (saline); # p < 0.05 versus OH (saline) (A–D). * p < 0.05 versus OH (saline) (E,F). n = 6 or 7 for each group.
