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. 2019 Aug 23;20(17):4112. doi: 10.3390/ijms20174112

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Association between IL-8 and increased adiposity in human adipose tissue. Subcutaneous adipose tissue was obtained from individuals with normoweight, overweight or obesity. (A) Direct correlation between adipose tissue IL-8 mRNA expression and the BMI. (B,C) Increased adipose tissue IL-8 mRNA and protein expression with increasing adiposity. IL-8 mRNA expression was detected by real-time RT-PCR and represented as fold change over controls. IL-8 protein expression was detected by immunohistochemistry and represented as staining intensity based on Aperio-positive pixel counts (Aperio software algorithm version 9.0). (D) Representative images are presented for IL-8 protein expression in the adipose tissue from individuals with normoweight, overweight or obesity. The arrowheads point to cells with intense staining for IL-8 protein. Correlation analysis was conducted using the non-parametric Spearman’s r test, and the group medians were compared using the non-parametric Kruskal-Wallis test.