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. 2019 Aug 24;20(17):4132. doi: 10.3390/ijms20174132

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effect of gene silencing Rab7 on the inhibition of vWF and P-selectin secretion by Sirt1/FoxO1 pathway activation. HUVECs were transfected with Rab7 siRNA for 24 h and incubated with 100 μg/mL ox-LDL and 10 μM RSV or 5 μM SRT1720 for 12 h. The secretion of vWF to extracellular (A) was determined by ELISA assay, and the secretion of vWF (B) and P-selectin (C) to cytomembrane was detected by flow cytometry. Values are presented as the means ± SD (ELISA assay: n = 6, flow cytometry: n = 3). Statistical significance between the ox-LDL treated group and other groups was determined by one-way ANOVA: Compared with the ox-LDL group, *** p < 0.001.