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. 2019 Aug 31;20(17):4270. doi: 10.3390/ijms20174270

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effects of sclerostin on osteoblast differentiation. Sclerostin produced by osteocytes inhibits Wnt/β-catenin signaling during early bone diseases in patients with cholestatic diseases [3]. This soluble protein is produced by osteocytes that differentiated from osteoblasts and prevents Wnt from binding to low-density lipoprotein receptor-related proteins-5/6 (LRP5/6) transmembrane receptors. This blockade prevents Wnt signaling and osteoblast differentiation to inhibit bone formation. LRP: lipoprotein receptor-related proteins; GSK3: glycogen synthase kinase 3, DKK: Dickkopf; sFRP: secreted frizzled-related protein; APC: adenomatosis polyposis coli; TCF: T-cell specific transcription factor.