Table 4.
Nicotine and nicotine-related alkaloids generated from E-liquid aerosol and tobacco smoke.
| Reference E-liquid | Marlboro® Red Cigarette | ||||||
|---|---|---|---|---|---|---|---|
| Compound | µg/mL of 420 µL of E-liquid (3 cigarette equivalent) (n = 3) * | µg/mL of 420 µL of E-liquid (3 cigarette equivalent) on disk (n = 3) @ | µg/mL of 45 puffs of E-liquid (3 cigarette equivalent) on disk (n = 3) # | % Recovery ^ | µg per 3 cigarette equivalent from the primary literature ! | µg in 45 puffs (3 cigarette equivalent) on disk (n = 8) # | Estimated % Recovery ^ |
| Nicotine | 21227 ± 37 | 20144 ± 1397 | 1414 ± 66 | 6.7 | 39480 [24] | 4719 ± 637 | 13.0 to 14.7% |
| 36435 [19] | |||||||
| 32700 [25] | |||||||
| 36210 [26] | |||||||
| 35160 [27] | |||||||
| 32025 [28] | |||||||
| Nornicotine | 11.5 ± 0.5 (0.11%) |
5.6 ± 0.9 (0.06%) |
Undetectable (0.00%) |
0.0 | 1509 [19] | 68.3 ± 9.1 (1.45%) | 4.5 to 8.9% |
| 768 [28] | |||||||
| 1526 [29] | |||||||
| Cotinine | 15.5 ± 0.2 (0.15%) |
14.2 ± 0.7 (0.14%) |
1.0 ± 0.1 (0.12%) |
6.6 | not available | 55.9 ± 8.2 (1.18%) |
not determinable |
| Anabasine | 7.8 ± 0.2 (0.07%) |
6.4 ± 0.9 (0.06%) |
0.5 ± 0.0 (0.07%) |
6.0 | 143 [19] | 17.9 ± 2.1 (0.38%) |
6.0 to 29.8% |
| 60 [28] | |||||||
| 296 [29] | |||||||
| Anatabine | 16.7 ± 0.6 (0.16%) |
14.3 ± 0.9 (0.14%) |
1.2 ± 0.2 (0.16%) |
7.0 | 1107 [19] | 46.2 ± 6.0 (0.98%) |
2.1 to 8.5% |
| 546 [28] | |||||||
| 2214 [29] | |||||||
| Myosmine | 14.1 ± 0 (0.13%) |
13.2 ± 1.0 (0.13%) |
1.1 ± 0.1 (0.15%) |
7.6 | 28 [29] | 40.8 ± 5.4 (0.87%) |
>100% |
Values given as Mean ± SEM determined from triplicates of three bottles of E-liquid or from Marlboro® Red cigarette. Values of in parenthesis represent alkaloid as a percent of nicotine. * = 420 µL of E-liquid is equivalent to amount vaporized in 45 puffs (i.e., 3 cigarette equivalent). @ = 420 µL is placed on a glass fiber disk and extracted in10 ml of methanol. # = 45 puffs aerosol or smoke extracted from glass fiber disks in 10 ml of methanol. ^ = percent of aerosol or smoke (based on total content) recovered from glass fiber disks. ! = Values found in the literature and adjusted to reflect the content in three cigarettes using 0.671 ± 0.005 g as the weight of tobacco in a Marlboro® Red cigarette.