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. 2019 Aug 28;20(17):4207. doi: 10.3390/ijms20174207

Table 1.

Effects of post-translational modifications on chaperone function. Overview of major post-translational modifications and their effect on chaperone function as covered in this review.

Chaperone Position Modification Effect
Hsp70 T13 Phosphorylation Centrosome localization
S19 Phosphorylation Promotes protein refolding and aggregate binding
S23 Phosphorylation Promotes protein refolding and aggregate binding
S25 Phosphorylation Promotes protein refolding and aggregate binding
T66 Phosphorylation Kinetochore microtubule localization
T226 Phosphorylation Centrosome localization
S362 Phosphorylation Centrosome localization
S486 Phosphorylation Stabilize Caspase-3 and inhibit apoptosis
T492 Phosphorylation Promotes growth
S495 Phosphorylation Promotes growth
T499 Phosphorylation Promotes growth
T504 Phosphorylation Promotes dimer assembly
S631 Phosphorylation Centrosome localization
T633 Phosphorylation Centrosome localization
T636 Phosphorylation Promotes Hsp40 STi1/HOP binding
N-term Acetylation Not specified
K77 Acetylation Promotes apoptosis
K126 Acetylation Promotes autophagy
Hsp40 S189 Sti1 (Hsp40) Localized to nucleus
T198 STi1 (Hsp40) Localized to nucleus