Table 1.
Effects of post-translational modifications on chaperone function. Overview of major post-translational modifications and their effect on chaperone function as covered in this review.
| Chaperone | Position | Modification | Effect |
|---|---|---|---|
| Hsp70 | T13 | Phosphorylation | Centrosome localization |
| S19 | Phosphorylation | Promotes protein refolding and aggregate binding | |
| S23 | Phosphorylation | Promotes protein refolding and aggregate binding | |
| S25 | Phosphorylation | Promotes protein refolding and aggregate binding | |
| T66 | Phosphorylation | Kinetochore microtubule localization | |
| T226 | Phosphorylation | Centrosome localization | |
| S362 | Phosphorylation | Centrosome localization | |
| S486 | Phosphorylation | Stabilize Caspase-3 and inhibit apoptosis | |
| T492 | Phosphorylation | Promotes growth | |
| S495 | Phosphorylation | Promotes growth | |
| T499 | Phosphorylation | Promotes growth | |
| T504 | Phosphorylation | Promotes dimer assembly | |
| S631 | Phosphorylation | Centrosome localization | |
| T633 | Phosphorylation | Centrosome localization | |
| T636 | Phosphorylation | Promotes Hsp40 STi1/HOP binding | |
| N-term | Acetylation | Not specified | |
| K77 | Acetylation | Promotes apoptosis | |
| K126 | Acetylation | Promotes autophagy | |
| Hsp40 | S189 | Sti1 (Hsp40) | Localized to nucleus |
| T198 | STi1 (Hsp40) | Localized to nucleus |