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. 2019 Aug 30;20(17):4260. doi: 10.3390/ijms20174260

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Construction and representation of multiple bipartite graphs. (a) Construct a lncRNA-disease association bipartite graph based on the known associations between lncRNAs and diseases, and its’ matrix representation A. (b) Construct lncRNA-miRNA interactions bipartite graph based on the known lncRNA-miRNA interactions, and its’ matrix representation B. (c) Construct miRNA-disease association bipartite graph based on known miRNA-disease associations, and its’ matrix representation C. (d) Calculate the lncRNA similarity, and construct the matrix representation L. (e) Calculate the disease similarity, and construct the matrix representation D.