Table 1.
Phosphorylation sites identified in members of the Hsp70, Hsp40, and Hsp110 chaperone families with known effects on their structure and function. hs: Homo sapiens; sc: Saccharomyces cerevisiae; ec: Escherichia coli; mm: Mus musculus.
| Chaperone | Phosphorylation site(s) | Structural/Functional consequence(s) | Reference |
|---|---|---|---|
| hsDnaJB1 | Ser149, Ser151 and Ser171 | Inhibition of HSF1-mediated transcription | [86] |
| hsCSP (DnaJC5) |
Ser10 | Order-to-disorder transition. Modulation of neurotransmitter release by inhibiting binding to syntaxin and synaptotagmin | [87] |
| hsCSP (DnaJC5) |
Ser10 and Ser34 | Protection of the presynaptic terminal by promoting HSP70 chaperone activity | [88] |
| hsHsp105α (HSPH1) |
Ser509 | Inhibition of the Hsp105-induced suppression of Hsc70-mediated refolding | [89] |
| hsHsp70 (HSPA1A) |
Ser631 | Regulation of SOD2 import into the mitochondria and redox balance | [90] |
| hsHsp70 (HSPA1A) |
Tyr524 | Enhanced nuclear accumulation and heat-shock injury resistance | [91] |
| hsHsc70 (HSPA8) |
Thr495 | Inhibition of Hsp70 ATPase and refolding activities | [92] |
| ecHsp70 (DnaK) |
Thr504 | Stabilization of Hsp70 antiparallel dimers to position the client for transfer to Hsp90 | [93] |
| hsHsc70 (HSPA8) |
Thr636 | Enhanced interaction with HOP | [94] |
| hsHsc70 (HSPA8) |
Ser631 and Ser633 | Recruitment of Hsc70 to the centrosomes leading to mitotic spindle elongation and prevention of apoptosis | [95] |
| scHsp70 (Ssa1) |
Thr36 | Regulation of the cell cycle progression | [96] |
| mmHsc70 (Hspa8) |
Tyr288 | Cell uptake of methotrexate | [97] |
| hsHsp70 (HSPA1A) |
Ser486 | Inhibition of apoptosis | [98] |
| hsHsp70 (HSPA1A) |
Thr66 | Promotion of K-fiber assembly and mitotic progression | [99] |