Figure 1.

L1CAM domain structure with known interaction sites. On the left, sites of direct interaction are indicated with solid black right-pointing arrows, and possible indirect activation with dashed left-pointing arrow. Arrows in blue indicate interactions that span several Ig (immunoglobulin like)- or FNIII (fibronectin type III) repeats. On the right, numbered amino acid residues, corresponding with different domains or repeats are indicated. The black triangles indicate the amino acid sequences encoded by alternatively spliced exons 2, 25 and 27.