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. 2019 Aug 26;20(17):4180. doi: 10.3390/ijms20174180

Figure 2.

Figure 2

L1CAM cleavage and nomenclature of L1CAM forms discussed in this review. (A) Structure of L1CAM including main cleavage sites. ADAM: A Disintegrin and metalloproteinase domain-containing protein. MMP: matrix metalloprotease. (B) Full-length L1CAM (FL) and forms resulting from proteolytic cleavage. ΔCT lacks the C-terminal domain, NT represents the soluble N-terminal domain, ΔNT lacks the N-terminal domain, CT represents the cytosolic C-terminal cleavage product. (C) Shows exosomal forms (Exo) corresponding with the full-length or proteolytic cleavage forms indicated in B.