Figure 5.

The binding modes of Compounds 7, 8, and 9 at the active site (amino acid residue SER280 in the Corey-Pauling-Koltun model, other amino acid residues in the line model and ligands in the stick model, among which Compound 7 is expressed in yellow; the receptor surface colored by the interpolated atomic charge—blue represents a positive value and red represents a negative value; the R2-position on ring A highlighted in a blue rectangle).