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. 2019 Aug 21;20(17):4090. doi: 10.3390/ijms20174090

Table 3.

The structure-activity relationships on Ring B.

NO. MS pIC50 ΔpIC50 NO. MS pIC50 ΔpIC50
12 graphic file with name ijms-20-04090-i017.jpg −0.1761 / 20 graphic file with name ijms-20-04090-i018.jpg −1.8129 –1.6368
9 graphic file with name ijms-20-04090-i019.jpg 0.1024 0.2785 21 graphic file with name ijms-20-04090-i020.jpg −2.1761 –2.0000
18 graphic file with name ijms-20-04090-i021.jpg −0.5682 –0.3921 22 graphic file with name ijms-20-04090-i022.jpg −3.2304 –3.0543
19 graphic file with name ijms-20-04090-i023.jpg −1.8451 –1.6690

NO.: Number of compounds; MS: Molecular structure; pIC50: −logIC50 (IC50: Half maximal inhibitory concentration, nM); ΔpIC50: The difference value of pIC50 between Compounds 9, 18, 19, 20, 21, 22, and 12, respectively.