. Author manuscript; available in PMC: 2019 Sep 17.

Published in final edited form as: J Pathol. 2019 Feb 20;247(5):574–588. doi: 10.1002/path.5229

Table 2.

Colonoscopy surveillance recommendations for individuals with germline pathogenic variants (high penetrance syndromes) [130].

Syndrome (Gene)	Family history of CRC	Age at CRC screening initiation	Screening interval if no adenomas

No mutation^a	No	50	10 years
	Yes (≥1 FDR)	40^b	5–10 years
FAP (APC)	N/A	10–15	1 year, colectomy if polyps too numerous
Lynch syndrome (MLH1, MSH2, MSH6, PMS2)	N/A	20–25	1–2 years until age 40, then every 1 year
MAP (MUTYH Biallelic)	N/A	25–30	1–3 years depending on polyp burden
Juvenile polyposis (SMAD4, BMPR1A)	N/A	15	1–3 years depending on polyp burden
Peutz-Jeghers (STK11)	N/A	15	2–3 years depending on polyp burden
Li Fraumeni (TP53)	N/A	20–25	3 years
Hereditary Breast	No	50	10 years
Ovarian Cancer	Yes	50 or per family history	5 years
(BRCA1/BRCA2)

^a.

Recommendations based in the guidelines from the National Comprehensive Cancer Network [71].

^b.

40 years old or 10 years earlier than the youngest-onset CRC in the family.

Abbreviations: CRC, colorectal cancer; FDR, first-degree relative; SDR, second-degree relative.