. Author manuscript; available in PMC: 2019 Sep 17.

Published in final edited form as: J Pathol. 2019 Feb 20;247(5):574–588. doi: 10.1002/path.5229

Table 4.

MLH1 and MSH2 missense substitutions in the InSiGHT and gnomAD databases.

Variant class and source	Missense substitution count	Average sequence analysis-based probability of pathogenicity

Class 4, 5	144	0.784
InSiGHTonly	135	0.790
InSiGHT and gnomAD	9	0.690
Class 3	1,299	0.391
InSiGHTonly	408	0.579
InSiGHT and gnomAD	176	0.388
gnomAD	891	0.306
Class 1, 2	45	0.260
InSiGHTonly	5	0.374
InSiGHT and gnomAD	40	0.246