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. Author manuscript; available in PMC: 2020 Feb 1.
Published in final edited form as: Biol Psychiatry. 2018 Jul 5;85(3):189–201. doi: 10.1016/j.biopsych.2018.06.019

Figure 6.

Figure 6.

Summary schematic showing projection-specific remodeling of basolateral amygdala (BLA) projection neurons (PNs) after chronic stress. BLA PNs targeting dorsomedial prefrontal cortex (BLA→dmPFC) and a subset of those not targeting dmPFC (BLA↛dmPFC) projecting to the nucleus accumbens (NAc) show dendritic hypertrophy with no change in spine density or number of mushroom-type mature spines and no alteration in excitatory transmission. BLA→ventral hippocampus (vHPC) PNs exhibit dendritic hypertrophy, increased spine density, and a preponderance of mature spines. BLA→vHPC PNs also show augmented excitatory transmission, which correlates with stress-induced anxiety-like behavior. mEPSC, miniature excitatory postsynaptic current.