FIG 1.
Structure and biological activity of antimycobacterial agents. (A and B) The activity of (A) 2504 and (B) 2178 against M. tuberculosis cells that were replicating (R) or nonreplicating (NR) in the 4-stress model as assessed by charcoal-agar resazurin assay (CARA) and their activity against human HepG2 cells. The CARAMBC is the concentration of compound used to reduce the signal to <1% of the fluorescent signal of the DMSO controls. (C to E) CFU/ml after 7 days of compound exposure of M. tuberculosis under (C) replicating conditions, (D) NR conditions in the 4-stress model, and (E) NR conditions in the nutrient starvation model. Data are means ± SD from one experiment representative of at least 3 independent experiments performed in triplicate using DMSO as the vehicle control.