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. 2019 Jul 9;10(4):e01405-19. doi: 10.1128/mBio.01405-19

TABLE 1.

Selection of resistant mycobacterial mutants

Clone mutational analysis result with the indicated compound, species (μM concn), FORa
2504, M. tuberculosis H37Rv (12.4), 6.8 × 10–8
2178, M. tuberculosis H37Rv (8), 5.6 × 10–9
2150, M. tuberculosis H37Rv (10), 1.1 × 10–8
SAR1, BCG (2 and 8), 4 × 10–8
Clone CorA mutation Other gene(s)d Clone CorA mutation Other gene Clone CorA mutation Other gene Clone CorA mutation Other gene(s)
1 E212D None 4 A317S rv1922 Y153b 5 L229V None 1 A317S vapB48
2 D285N rv1520 S317+ ppsE W1428R rocE V270+ 6 D285G None 2 A317S corA onlyc
3 E212D None 7 L229V None 3 L229V fadD30, ppsB/C
deleted
4 G299S corA onlyc
a

FOR, frequency of resistance.

b

Stop codon.

c

For this clone, corA alone was sequenced; whole-genome sequencing was not carried out.

d

“+” denotes a frameshift mutation.