TABLE 1.
Clone mutational analysis result with the indicated compound, species (μM concn), FORa
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2504, M. tuberculosis H37Rv (12.4), 6.8 × 10–8 |
2178, M. tuberculosis H37Rv (8), 5.6 × 10–9 |
2150, M. tuberculosis H37Rv (10), 1.1 × 10–8 |
SAR1, BCG (2 and 8), 4 × 10–8 |
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Clone | CorA mutation | Other gene(s)d | Clone | CorA mutation | Other gene | Clone | CorA mutation | Other gene | Clone | CorA mutation | Other gene(s) |
1 | E212D | None | 4 | A317S | rv1922 Y153b | 5 | L229V | None | 1 | A317S | vapB48 |
2 | D285N | rv1520 S317+ ppsE W1428R rocE V270+ | 6 | D285G | None | 2 | A317S | corA onlyc | |||
3 | E212D | None | 7 | L229V | None | 3 | L229V |
fadD30, ppsB/C deleted |
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4 | G299S | corA onlyc |
FOR, frequency of resistance.
Stop codon.
For this clone, corA alone was sequenced; whole-genome sequencing was not carried out.
“+” denotes a frameshift mutation.