Figure 2.

Amyloid precursor protein (APP) processing pathways. The non-amyloidogenic pathway (a) occurs upon sequential cleavage by α- and γ-secretases (non-pathological situation). The amyloidogenic pathway route (b) occurs when cleavage is carried out sequentially by β- and γ secretases (pathological situation). Letters α, β, and γ represent each type of secretase. APP: Amyloid precursor protein, APPsα: Soluble α-APP, APPsβ: Soluble β-APP. Omega-3 polyunsaturated fatty acids, proposed to inhibit APP processing, are shown in orange dashed lines.