Fig. 4.

LncRNA DNM3OS acted as a molecular sponge of miR-126. (a) The predicted binding sequences of miR-126 in DNM3OS using starBase v2.0. (b) The luciferase intensity of cells transfected with DNM3OS wild-type and miR-126 was significantly reduced. (c) The expression of miR-126-5p was negatively associated to DNM3OS in CHON-001 cells by RT-qPCR. (d) MiR-126-5p inhibitor reversed the promotion effects of siDNM3OS on miR-126-5p level as indicated by RT-qPCR. (e) The inhibitory effects of siDNM3OS on cells viability were weakened by miR-126 inhibitor. ^aP < 0.05 vs. DNM3OS-WT or Blank or MC, ^bP < 0.05 vs. NC or M, ^cP < 0.05 vs. DNM3OS or IC, ^dP < 0.05 vs. I, ^eP < 0.05 vs. siDNM3OS. WT: wild-type; MUT: mutated-type; NC: negative control; mimic: miR-126 mimic; M: miR-126 mimic; I: miR-126 inhibitor; MC: miR-126 mimic control; IC: miR-126 inhibitor control; siDNM3OS: small interfering dynamin 3 opposite strand